CBD (cannabidiol) Research is still in the early stages, however, the research that is out is quite amazing if you would like to know more take a look at these amazing research articles.  Don’t take our word for it check out what the experts are saying.

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*The following are links that connect directly to articles and research that have been published regarding CBD. To open each link simply hold down the control button on your keyboard then hold the cursor over the desired link and double right click.

ALZHEIMER’S DISEASE/ DEMENTIA

• Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders (PubMed)
• Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/ PS1∆E9 mice
• (PubMed)(Psychopharmacology August 2014, Volume 231, Issue 15, pp 3009-3017)
• Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

ANTIOXIDANT

• Understanding the molecular aspects of tetrahydrocannabinol and cannabidiol as antioxidants (PubMed)

ANXIETY

•  Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients (Pubmed)
• Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report (Pubmed)

ARTHRITIS

•  The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis (PubMed)

BONES/ STEM CELLS

•  Increase of mesenchymal stem cell migration by cannabidiol via activation of p42/44 MAPK

CANCER

 General

• Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1
• Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) bycannabidiol: a novel mechanism for cannabinoid-induced cell death

Bladder cancer

• TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer

Brain/Glioma/Spinal cancer

• Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87- MG and T98G glioma cells through a multitarget effect

Breast cancer

• Cannabinoids: a new hope for breast cancer therapy?
• Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells

Colon cancer

• Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol

Leukemia

• Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression

Lung cancer

• Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1

Pancreatic cancer

• Cannabinoids in pancreatic cancer: Correlation with survival and pain

Prostate cancer

• Towards the use of non-psychoactive cannabinoids for prostate cancer

CELLULAR

•  Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors
• Increase of mesenchymal stem cell migration by cannabidiol via activation of p42/44 MAPK

DIABETES

• Cannabidiol lowers incidence of diabetes in non-obese diabetic mice

EPILEPSY

• Chronic administration of cannabidiol to healthy volunteers and epileptic patients
• Hypnotic and antiepileptic effects of cannabidiol
• The findings published in the Journal of Biological Chemistry could provide a new basis for developing CBD-based treatments for pediatric epilepsy

HEART

•  Is the cardiovascular system a therapeutic target for cannabidiol?
• Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
• Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury

INTESTINAL INFLAMMATION

•  Cannabidiol in inflammatory bowel diseases: a brief overview
• Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis

LIVER

•  Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats
• Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy

MEMORY

• Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders
•  Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1∆E9 mice

 

 MULTIPLE SCLEROSIS

•  Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: a role for A2A receptors
• Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice

NAUSEA

•  Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus

NEUROPATHY (PERIPHERAL NEUROPATHY)

•  Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1A receptors without diminishing nervous system function or chemotherapy efficacy

NEUROPROTECTANT

•  Cannabidiol: a promising drug for neurodegenerative disorders?
• Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders
• Neuroprotection and reduction of glial reaction by cannabidiol treatment after sciatic nerve transection in neonatal rats
• Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function
• Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta- amyloid-induced toxicity in PC12 cells
• Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance

PAIN

• Cannabinoids in the management of difficult to treat pain
• The Endocannabinoid System, Cannabinoids, and Pain
• Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1A receptors without diminishing nervous system function or chemotherapy efficacy

PTSD

•  Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: possible involvement of 5HT1A receptors
• http://www.ncbi.nlm.nih.gov/pubmed/22979992

PSYCHOSIS/ SCHITZOPHRENIA

 

 

• Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
• A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation

STEM CELLS

•  Increase of mesenchymal stem cell migration by cannabidiol via activation of p42/44 MAPK

MIGRAINES

• Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science.

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